EXPERIMENTAL PARTICIPATION OF PHARMACOLOGICAL SUBSTANCES IN MECHANISMS OF LEAD ACETATE TOXICITY

The aim of the work is to study pharmacological substances that play a role eNOS expression regulators in modification lead intoxication effects experiment. Materials and methods. In experiment, linear male rats same age were used: intact with (120 heads). design was following: group 1 – control; 2 acetate solution; 3 + L-nitroarginine methyl ester; 4 5 L-arginine; 6 L-arginine. research carried out state redox reactions, content nitric oxide (NOx) stable metabolites, lipid profile, level NO-synthase (eNOS) vascular endothelium, main processes urination activity Na /K -ATPase renal tissue layers, as well liver. results subjected statistical processing. Results. Saturnism caused oxidative stress development, decrease NO x blood plasma, violation L-arginine for bioavailability, an endothelial dysfunction. Indicators impaired function glomerular filtration rate (GFR), tubular reabsorption water, sodium, activity. damage hepatocytes evidenced by changes organ-specific enzymes -ATPase. exhibited antioxidant properties, increased expression. ester inhibitor showed opposite Conclusion. Biochemical markers kidney liver cells during saturnism are indicators stress, deficiency hemodynamic disturbances them. These mechanisms involved following substances: inhibitor, ester, which enzyme, inducer, L-arginine, this indicator severity. toxicity have been implicated cholesterol metabolism, contributing reduced availability production. Therefore, use can be recommended regulator NO-producing other pathologies.